Search results for "Group F"

Behavioural responses of fish groups exposed to a predatory threat under elevated CO2

2019

Most of the studies dealing with the effects of ocean acidification (OA) on fish behaviour tested individuals in isolation, even when the examined species live in shoals in the wild. Here we evaluated the effects of elevated CO2 concentrations (i.e. ∼900 μatm) on the shelter use and group cohesion of the gregarious damselfish Chromis viridis using groups of sub-adults exposed to a predatory threat. Results showed that, under predatory threat, fish reared at elevated CO2 concentrations displayed a risky behaviour (i.e. decreased shelter use), whereas their group cohesion was unaffected. Our findings add on increasing evidence to account for social dynamics in OA experiments, as living in gro…

Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection

2019

CD4+ T cells contribute critically to a protective immune response during intestinal infections, but have also been implicated in the aggravation of intestinal inflammatory pathology. Previous studies suggested that T helper type (Th)1 and Th17 cells depend on de novo fatty acid (FA) synthesis for their development and effector function. Here, we report that T-cell-specific targeting of the enzyme acetyl-CoA carboxylase 1 (ACC1), a major checkpoint controlling FA synthesis, impaired intestinal Th1 and Th17 responses by limiting CD4+ T-cell expansion and infiltration into the lamina propria in murine models of colitis and infection-associated intestinal inflammation. Importantly, pharmacolog…

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult.

2019

International audience; Microbes colonize all body surfaces at birth and participate in the development of the immune system. In newborn mammals, the intestinal microbiota is first shaped by the dietary and immunological components of milk and then changes upon the introduction of solid food during weaning. Here, we explored the reactivity of the mouse intestinal immune system during the first weeks after birth and into adulthood. At weaning, the intestinal microbiota induced a vigorous immune response—a “weaning reaction”—that was programmed in time. Inhibition of the weaning reaction led to pathological imprinting and increased susceptibility to colitis, allergic inflammation, and cancer …

Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs

2017

Nussbaum et al. found that tumor suppression through innate lymphoid cells (ILCs) cannot be predicted solely based on the ILC phenotype and lineage but that their immune properties are shaped both by their ontogeny and by the tissue microenvironment they reside in.

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

2008

Background and Aims IL-17–producing CD4 + T-helper cells (Th17) contribute to chronic autoimmune inflammation in the brain, and levels of Th17-derived cytokines increase in patients with colitis, suggesting a role in pathogenesis. We analyzed the roles of Th17 cells and the transcription factor retinoic acid receptor-related organ receptor (ROR)γ, which regulates Th17 differentiation, in chronic intestinal inflammation. Methods Using an adoptive transfer model of colitis, we compared the colitogenic potential of wild-type, interleukin-17A (IL-17A)–, IL-17F–, IL-22–, and RORγ-deficient CD4 + CD25 − T cells in RAG1-null mice. Results Adoptive transfer of IL-17A–, IL-17F–, or IL-22–deficient T…

IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo

2011

The transcription factor IRF4 is involved in several T-cell-dependent chronic inflammatory diseases. To elucidate the mechanisms for pathological cytokine production in colitis, we addressed the role of the IRF transcription factors in human inflammatory bowel disease (IBD) and experimental colitis.IRF levels and cytokine production in IBD patients were studied as well as the effects of IRF4 deficiency in experimental colitis.In contrast to IRF1, IRF5, and IRF8, IRF4 expression in IBD was augmented in the presence of active inflammation. Furthermore, IRF4 levels significantly correlated with IL-6 and IL-17 mRNA expression and to a lesser extent with IL-22 mRNA expression in IBD. To further …

Using Power as a Negative Cue: How Conspiracy Mentality Affects Epistemic Trust in Sources of Historical Knowledge.

2018

Classical theories of attitude change point to the positive effect of source expertise on perceived source credibility persuasion, but there is an ongoing societal debate on the increase in anti-elitist sentiments and conspiracy theories regarding the allegedly untrustworthy power elite. In one correlational ( N = 275) and three experimental studies ( N = 195, N = 464, N = 225), we tested the novel idea that people who endorse a conspiratorial mind-set (conspiracy mentality) indeed exhibit markedly different reactions to cues of epistemic authoritativeness than those who do not: Whereas the perceived credibility of powerful sources decreased with the recipients' conspiracy mentality, that o…

Group fitness activities on elderly: who is eligible and who is not.

2012

Introduction While it is impossible to prevent every injury, literature suggests that injury rates could be reduced by 25% if people took appropriate preventative action. On the other side, one major problem of Group Fitness Instructors is to find the right intensity/level suitable for every attendee during classes (e.g. ballroom dancing). Therefore, the aim of this study was to examine the opportunity to adopt already validated function ability tests on group fitness activities with the aim to prevent injuries and maintain or increase quality of life. Methods The study was conducted with a quasi-experimental design. The Berg Balance Scale (BBS) and the Barthel index (BI) were administered …

Awareness level of gender stereotype and stereotype threat effect on ingroup favoritism bias in mixed-gender basketball teams.

2016

Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach

2013

Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss), nasal wash (NW) and plasma (P) from Healthy Controls (HC) and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORγ(t) and FOXP3 in peripheral blood T-lymphocytes from intermittent and mild-moderate asthma. The effect of Budesonide and Formoterol was tested "in vitro" on IL-17A, RORγ(t) and FOXP3 expression in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis patients, and on nasal and bronchial epithelial cells stimulated with NW and Ss from mild-moderate asthma/persistent rhinitis. Further, the effect of …